Aging HSC Epigenome  

This site provides access to datasets described in this manuscript.

 
 
Epigenetic dysregulation underlying HSC aging

Deqiang Sun*, Min Luo*, Mira Jeong*, Benjamin Rodriguez, Rebecca Hannah, Zheng Xia, Hui Wang, Thuc Le, Kym F. Faull, Rui Chen, Hongcang Gu, Christoph Bock, Alex Meissner, Berthold Gƶttgens, Gretchen J. Darlington#, Wei Li#, and Margaret A. Goodell#

Visulization through Track Hub

You may go to UCSC genome browser mm9, and mannually load the track hub http://dldcc-web.brc.bcm.edu/lilab/deqiangs/data/GO/Hub/tracks.txt.

Or you can do this by simply clicking this link "HSC Aging Hub".

Visulization through Track Text

Load all following several types of tracks by clicking here.

 

Explanation of tracks

1. Visualization of methylation ratios.
Basal methylation ratios at each CpG are shown as upward black bars, while sequencing coverage at each CpG is shown as downward grey bars. 0% methylation are represented as grey bars only. The methylation ratio difference track (Old minus Young) shows the differential methylation ratios with upward black bars for hyper- and downward grey bars for hypo-methylation in Old HSCs at each CpG.
See the graphical illustration on gene Mn1 here.

2. Visualization of differentially methylated Cpgs(DMCs) and regions(DMRs).
This track shows position of DMCs in bed track. The hypermethylation and hypomethylation are represented by blue and red bars.

3. Visualization of RNA-Seq signals.
This track shows the signals from RNA-Seq data.

4. Visualization of Histone Modification ChIP-Seq signals.
This track shows the signals from H3K4me3, H3K27me3 and H3K36me3 ChIP-Seq data.