de novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation  

This site provides access to datasets described in this manuscript.

 
 
de novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation

Grant A. Challen, Deqiang Sun*, Mira Jeong*, Jonathan S. Berg*, Jaroslav Jelinek, Christoph Bock, Min Luo, Aparna Vasanthakumar, Hongcang Gu, Yuanxin Xi, Shoudan Liang, Yue Lu, Gretchen J. Darlington, Alexander Meissner, John-Pierre J. Issa, Lucy A. Godley, Wei Li#, and Margaret A. Goodell#


0. Load all following three types of tracks by clicking here. See the graphical illustration on gene Mn1 here.

1. Visualization of methylation ratios of each sample.
In control and Dnmt3a-KO HSCs tracks, basal methylation ratios at each CpG are shown as upward black bars, while sequencing coverage at each CpG are shown as downward grey bars. 0% methylation are represented as grey bars only. The Dnmt3a-KO minus control track shows the differential methylation ratios with upward black bars for hyper- and downward grey bars for hypo-methylation in Dnmt3a-KO HSCs at each CpG.

2. Visualization of each nucleotide of each read.
These track show reads' different nucleotides than the reference sequence.

3. Visualization of differentially methylated Cpgs(DMCs).
Thistrack shows position of DMCs in bed track. The hypermethylation and hypomethylation are represented by blue and red bars.